We apply fundamental principles from the physical and life sciences to address pressing and emerging challenges with applications to human health and well-being. We use techniques like activity-based assays, 3D microfabrication, and autonomous capillary microfluidics, to tackle real world challenges such as therapeutic drug monitoring to prevent treatment failure and improve health outcomes. We aim to develop user-friendly tools that can be used where needed whether in a doctor’s office, person's home, or field site.